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Accelerate preclinical success with expert nucleic acid CRO services

Axolabs’ CRO platform provides comprehensive preclinical support for nucleic acid therapeutics, integrating advanced in silico design, preclinical screening, and in vitro testing to drive rapid lead optimisation. Working in concert with our CDMO team, we ensure data-driven decisions and a smooth transition from discovery through to clinical development and commercial success.

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Services CRO

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Axolabs’ CRO platform provides comprehensive preclinical support for nucleic acid therapeutics, integrating advanced in silico design, preclinical screening, and in vitro testing to drive rapid lead optimisation. Working in concert with our CDMO team, we ensure data-driven decisions and a smooth transition from discovery through to clinical development and commercial success.

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Services CRO

In silico & bioinformatics

Our proprietary algorithms predict off-target interactions, ensure species cross-reactivity, and model secondary structures before benchwork begins.

Highlights
  • In silico screening streamlines lead selection.
  • Sequence-specific modelling reduces downstream failures.
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Services CRO

Rational design & synthesis

We integrate chemical modifications to boost oligonucleotide stability, lower immunogenicity, and enable targeted delivery for siRNA, ASO, CRISPR gRNAs, and more.

Highlights
  • Solid-phase synthesis at multiple scales.
  • On-resin or post-synthetic conjugation for peptides, lipids, or GalNAc.
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Two scientists in lab coats and safety glasses collaborate, with one drawing chemical structures and graphs on a transparent glass board.
Two scientists wearing lab coats and protective glasses observe an automated synthesis machine operating inside a ventilated enclosure in a laboratory.
Services CRO

Preclinical screening

Automated synthesis, rapid purification, and multiplexed assays let us quickly evaluate oligonucleotide libraries for efficacy, specificity, and safety.

Highlights
  • Parallel screening via Quantigene™, qPCR, RNA-Seq.
  • Real-time data speeds up structure-activity relationship (SAR) studies.
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A scientist wearing a lab coat and blue gloves carefully injects a solution into a round-bottom flask on a magnetic stirrer in a laboratory setup.
A scientist wearing blue gloves organises labelled sample vials with blue caps in a red rack on a laboratory bench under bright lighting.
Services CRO

Cell-based evaluations

Our robust in vitro platforms verify on-target effects, assess cytotoxicity, and measure immunostimulation, guiding early go/no-go decisions.

Highlights
  • xCELLigence® real-time monitoring of cell growth/viability.
  • Flow cytometry for detailed phenotypic and surface-marker analysis.
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A scientist wearing blue gloves handles a red rack filled with labelled sample tubes inside a white container of dry ice in a laboratory.
Services CRO

Advanced bioanalytics

Specialized PNA-HPLC, LC-MS/MS, and cytokine profiling provide deep insight into oligonucleotide kinetics, metabolism, and immune responses.

Highlights
  • Extraction-free detection of single- and double-stranded oligonucleotides.
  • MRM-based quantification of parent drug and metabolites.
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A scientist wearing protective glasses and blue gloves operates a thermal cycler in a laboratory, loading a red sample plate into the open device.
A scientist wearing blue gloves places a labelled sample vial into an autosampler tray filled with other vials capped with blue lids in a laboratory setting.

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Partner with a global leader in oligonucleotide research, development, and manufacturing. Whether you need early-stage optimisation, large-scale GMP production, or specialised analytical support, Axolabs’ experts are ready to help. Get in touch to discuss your project, request a capabilities overview, or schedule a technical consultation.

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