CRO Services
Accelerate preclinical success with expert nucleic acid CRO services
Axolabs’ CRO platform provides comprehensive preclinical support for nucleic acid therapeutics, integrating advanced in silico design, preclinical screening, and in vitro testing to drive rapid lead optimisation. Working in concert with our CDMO team, we ensure data-driven decisions and a smooth transition from discovery through to clinical development and commercial success.
In silico & bioinformatics
Our proprietary algorithms predict off-target interactions, ensure species cross-reactivity, and model secondary structures before benchwork begins.
- In silico screening streamlines lead selection.
- Sequence-specific modelling reduces downstream failures.
Rational design & synthesis
We integrate chemical modifications to boost oligonucleotide stability, lower immunogenicity, and enable targeted delivery for siRNA, ASO, CRISPR gRNAs, and more.
- Solid-phase synthesis at multiple scales.
- On-resin or post-synthetic conjugation for peptides, lipids, or GalNAc.
Preclinical screening
Automated synthesis, rapid purification, and multiplexed assays let us quickly evaluate oligonucleotide libraries for efficacy, specificity, and safety.
- Parallel screening via Quantigene™, qPCR, RNA-Seq.
- Real-time data speeds up structure-activity relationship (SAR) studies.
Cell-based evaluations
Our robust in vitro platforms verify on-target effects, assess cytotoxicity, and measure immunostimulation, guiding early go/no-go decisions.
- xCELLigence® real-time monitoring of cell growth/viability.
- Flow cytometry for detailed phenotypic and surface-marker analysis.
Advanced bioanalytics
Specialized PNA-HPLC, LC-MS/MS, and cytokine profiling provide deep insight into oligonucleotide kinetics, metabolism, and immune responses.
- Extraction-free detection of single- and double-stranded oligonucleotides.
- MRM-based quantification of parent drug and metabolites.
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Axolabs’ CRO platform provides comprehensive preclinical support for nucleic acid therapeutics, integrating advanced in silico design, preclinical screening, and in vitro testing to drive rapid lead optimisation. Working in concert with our CDMO team, we ensure data-driven decisions and a smooth transition from discovery through to clinical development and commercial success.
Contact us
Find out morePartner with a global leader in oligonucleotide research, development, and manufacturing. Whether you need early-stage optimisation, large-scale GMP production, or specialised analytical support, Axolabs’ experts are ready to help. Get in touch to discuss your project, request a capabilities overview, or schedule a technical consultation.